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A Giant Stumped by Dissolution
The story of a pharma giant
A leading global consulting firm, renowned for advising the world's largest enterprises, approached Neu Nutrition with a critical challenge they faced on behalf of their client, a multinational pharmaceutical giant. The issue was a persistent, complex dissolution problem in a crucial tablet formulation being produced at one of their major manufacturing facilities in Western India.
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This wasn't a minor hiccup; it was a significant impediment. Despite extensive internal efforts, the pharma company's own R&D and production teams were struggling to pinpoint the exact root cause of the suboptimal dissolution profile. This meant potential delays in market release, compliance risks, and a direct impact on the product's therapeutic efficacy. The consultant firm, recognizing the highly specialized nature of the problem, sought a partner with unparalleled formulation and process optimization expertise, capable of diagnosing and resolving an issue that had baffled even a global industry leader.
The Neu Nutrition Solution: On-Site Expertise, Data-Driven Precision
Neu Nutrition accepted the challenge, understanding the high stakes involved for both the consulting firm and their pharmaceutical client. Our elite formulation expert was immediately dispatched to the manufacturing site in Western India, a testament to our agile and on-the-ground problem-solving approach.
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Our expert didn't just observe; they meticulously analyzed the vast datasets generated across the entire tablet manufacturing process. This included a deep dive into formulation data, granular details from the granulation process, specifics of blending uniformity, and precise measurements from compression parameters. It was a comprehensive, data-driven investigation designed to uncover hidden correlations and critical deviations.
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Through this rigorous analysis, our expert pinpointed the elusive culprits: the problem lay not in the formulation's active ingredients, but in nuanced process parameters. Specifically, deviations in granulation time, the precise addition of granulation liquid, the applied compression force, and the crucial ratio of fines within the blend were identified as the key variables negatively impacting dissolution. These were the subtle, yet powerful, levers that the company's internal teams had struggled to identify.
The Breakthrough: Optimized Process, Restored Efficacy
With the problem precisely diagnosed, Neu Nutrition provided clear, actionable recommendations. Collaborating closely with the on-site production team, our expert guided the modification of these critical process parameters. Adjustments were made to the granulation profile, the liquid addition methodology was refined, the compression force was optimized for ideal tablet porosity, and the blend's fines ratio was brought within optimal specifications.
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The results were immediate and conclusive. These precise modifications to the manufacturing process parameters completely resolved the dissolution issue, achieving the optimal release profile that the pharmaceutical giant had been striving for. What a global leader with vast resources couldn't solve internally, Neu Nutrition's specialized, data-driven formulation expertise rectified. This partnership not only restored product efficacy and ensured regulatory compliance but also cemented our role as a critical problem-solver for the most complex challenges in pharmaceutical manufacturing. It was a clear demonstration that integrated, on-site scientific expertise can unlock solutions that transform production bottlenecks into seamless success.